abstract：BACKGROUND:Self-report questionnaires are widely used to assess physical function in older adults. However, they often lack a clear frame of reference and hence interpreting and rating task difficulty levels can be problematic for the responder. Consequently, the usefulness of traditional self-report questionnaires for...

journal_title：Experimental gerontology

authors： Balachandran A,N Verduin C,Potiaumpai M,Ni M,Signorile JF

更新日期：2016-08-01 00:00:00

abstract：:Reductions in physical performance, cognitive impairment (CI) and decline (CD), are common in older age, but few prospective cohort studies have considered the relationship between these domains. In this study we investigated whether reduced physical performance and low handgrip/lower limbs strength, could predict a h...

journal_title：Experimental gerontology

authors： Veronese N,Stubbs B,Trevisan C,Bolzetta F,De Rui M,Solmi M,Sartori L,Musacchio E,Zambon S,Perissinotto E,Crepaldi G,Manzato E,Sergi G

更新日期：2016-08-01 00:00:00

abstract：:During the course of life, cyclic females face a state of midlife transition that occurs in a fully functioning neurological system, and results in reproductive senescence. The authors' hypothesis was that changes in the activity noradrenergic neurons may be one of the factors involved in this phenomenon. The aim of t...

journal_title：Experimental gerontology

authors： Nicola AC,Leite CM,Nishikava MM,de Castro JC,Anselmo-Franci JA,Dornelles RC

更新日期：2016-08-01 00:00:00

abstract：BACKGROUND:The loss of muscle mass is considered to be a major factor contributing to strength decline during aging. β-Hydroxy-β-Methylbutyrate (HMB), a metabolite of leucine has been shown to enhance muscle protein synthesis and attenuate loss of muscle mass by multiple pathways. However, the production and regulation...

journal_title：Experimental gerontology

authors： Shreeram S,Ramesh S,Puthan JK,Balakrishnan G,Subramanian R,Reddy MT,Pereira SL

更新日期：2016-07-01 00:00:00

abstract：AIM:Sirtuins are proteins that connect energy metabolism, oxidative stress and aging. Expression of heat shock proteins (Hsps) is regulated by heat shock factors (HSFs) in response to various environmental and physiological stresses, such as oxidative stress. Oxidative stress accumulates during aging which makes cells ...

journal_title：Experimental gerontology

authors： Karvinen S,Silvennoinen M,Vainio P,Sistonen L,Koch LG,Britton SL,Kainulainen H

更新日期：2016-06-15 00:00:00

abstract：PURPOSE:The elderly lose skeletal muscle mass with age, which may be detrimental for function and quality of life. Both inactivity and heavy resistance exercise are known to have marked but opposite effects upon muscle mass. However, the potential effects of daily physical activity upon muscle protein synthesis (MPS) a...

journal_title：Experimental gerontology

authors： Bülow J,Agergaard J,Kjaer M,Holm L,Reitelseder S

更新日期：2016-06-15 00:00:00

abstract：:Age-related hearing loss (AHL) is a progressive neurodegenerative disease that is largely silent in its initial stages. There is no sensitive blood biomarker for diagnosis or early detection of AHL. MicroRNAs (miRNAs or miRs) are abundant and highly stable in blood, and have been recently described as powerful circula...

journal_title：Experimental gerontology

authors： Pang J,Xiong H,Yang H,Ou Y,Xu Y,Huang Q,Lai L,Chen S,Zhang Z,Cai Y,Zheng Y

更新日期：2016-04-01 00:00:00

abstract：:Raw bioelectrical impedance analysis (BIA) data [resistance (R); reactance (Xc)] through bioelectrical impedance vector analysis (BIVA) and phase angle (PhA) have been used to evaluate cellular function and hydration status. The purpose of this investigation was to examine the effects of resistance training (RT) on cl...

journal_title：Experimental gerontology

authors： Fukuda DH,Stout JR,Moon JR,Smith-Ryan AE,Kendall KL,Hoffman JR

更新日期：2016-02-01 00:00:00

abstract：:Alterations in the hypothalamic-pituitary-gonadal axis in females determine the transition from regular to irregular reproductive cycles, with loss of fertility. Stimulation of noradrenergic neurons of the anteroventral periventricular neurons (AVPV) is essential for regular reproductive cycles. Therefore, we examined...

journal_title：Experimental gerontology

authors： Ferreira LB,de Nicola AC,Anselmo-Franci JA,Dornelles RC

更新日期：2015-12-01 00:00:00

abstract：OBJECTIVES:To evaluate the effects of elastic band resistance training in combination with nutrient supplementation on muscular strength and the ability to perform mobility-related activities of daily living in older adults living in retirement care facilities. DESIGN:Randomized controlled trial, with a 6-month interv...

journal_title：Experimental gerontology

authors： Oesen S,Halper B,Hofmann M,Jandrasits W,Franzke B,Strasser EM,Graf A,Tschan H,Bachl N,Quittan M,Wagner KH,Wessner B

更新日期：2015-12-01 00:00:00

abstract：:Aberrant mineralization of soft connective tissues (ectopic calcification) may occur as a frequent age-related complication. Still, it remains unclear the role of mesenchymal cell donor's age and of replicative senescence on ectopic calcification. Therefore, the ability of cells to deposit in-vitro hydroxyapatite crys...

journal_title：Experimental gerontology

authors： Boraldi F,Bartolomeo A,Di Bari C,Cocconi A,Quaglino D

更新日期：2015-12-01 00:00:00

abstract：:Aging is characterized by the progressive decline in mass and function of the skeletal muscle along with increased susceptibility to inflammation, oxidative stress, and atrophy. In this study, we investigate the effect of intermittent bout and single bout exercise training on inflammatory molecules in young (3 months)...

journal_title：Experimental gerontology

authors： Kim JS,Yi HK

更新日期：2015-12-01 00:00:00

abstract：:Delirium is an acute-onset syndrome that exacerbates patients' condition and significantly increases consequential morbidity and mortality. There is no comprehensive, cellular and tissue-level, pathophysiological theory. The melatonin hormone imbalance has been shown to be linked to circadian rhythms, sleep-wake cycle...

journal_title：Experimental gerontology

authors： Piotrowicz K,Klich-Rączka A,Pac A,Zdzienicka A,Grodzicki T

更新日期：2015-12-01 00:00:00

abstract：:Telomere length is considered as a biological marker for aging. It is expected that telomeres shorten with age and with conditions associated with oxidative stress and inflammation. Both are present in patients with chronic kidney disease (CKD) who have a very high cardiovascular risk. We investigated whether CKD dura...

journal_title：Experimental gerontology

authors： Raschenberger J,Kollerits B,Titze S,Köttgen A,Bärthlein B,Ekici AB,Forer L,Schönherr S,Weissensteiner H,Haun M,Wanner C,Eckardt KU,Kronenberg F,GCKD study Investigators.

更新日期：2015-12-01 00:00:00

abstract：:With many caveats to the traditional vertebrate species pertaining to biogerontology investigations, it has been suggested that a most informative model is the one which: 1) examines closely related species, or various members of the same species with naturally occurring lifespan variation, 2) already has adequate med...

journal_title：Experimental gerontology

authors： Gilmore KM,Greer KA

更新日期：2015-11-01 00:00:00

abstract：:Free-living organisms are exposed to a wide range of stressors, all of which can disrupt components of stress-related and detoxification physiology. The subsequent accumulation of somatic damage is widely believed to play a major role in the evolution of senescence. Organisms have evolved sophisticated physiological r...

journal_title：Experimental gerontology

authors： Watson H,Cohen AA,Isaksson C

更新日期：2015-11-01 00:00:00

abstract：INTRODUCTION:Chronically elevated circulating inflammatory markers are common in older persons but mechanisms are unclear. Many blood transcripts (>800 genes) are associated with interleukin-6 protein levels (IL6) independent of age. We aimed to identify gene transcripts statistically mediating, as drivers or responder...

journal_title：Experimental gerontology

authors： Pilling LC,Joehanes R,Melzer D,Harries LW,Henley W,Dupuis J,Lin H,Mitchell M,Hernandez D,Ying SX,Lunetta KL,Benjamin EJ,Singleton A,Levy D,Munson P,Murabito JM,Ferrucci L

更新日期：2015-10-01 00:00:00

abstract：BACKGROUND:Epidemiological and objective studies report an association between sedentary time and lower risk of the metabolic syndrome (MetS) and its risk factors in young and middle-age adults. To date, there is a lack of objective data on the association between sedentary time and MetS among older adults. METHODS:Th...

journal_title：Experimental gerontology

authors： Mankowski RT,Aubertin-Leheudre M,Beavers DP,Botoseneanu A,Buford TW,Church T,Glynn NW,King AC,Liu C,Manini TM,Marsh AP,McDermott M,Nocera JR,Pahor M,Strotmeyer ES,Anton SD,LIFE Research Group.

更新日期：2015-10-01 00:00:00

abstract：:The maximal lifespan (MLS) of mammals is inversely correlated with the peroxidation index, a measure of the proportion and level of unsaturation of polyunsaturated fatty acids (PUFA) in membranes. This relationship is likely related to the fact that PUFA are highly susceptible to damage by peroxidation. Previous compa...

journal_title：Experimental gerontology

authors： Cortie CH,Hulbert AJ,Hancock SE,Mitchell TW,McAndrew D,Else PL

更新日期：2015-10-01 00:00:00

abstract：:We investigated the effect of resistance training on irisin expression with improvement in muscle strength and function in aged mice and human. In the mice study, 19 months old male C57BL/6 mice were randomly assigned into two groups; control group and resistance exercise group. Ladder climbing exercise with tail weig...

journal_title：Experimental gerontology

authors： Kim HJ,So B,Choi M,Kang D,Song W

更新日期：2015-10-01 00:00:00

abstract：:Apoptosis plays an important role in atrophy and sarcopenia in skeletal muscle. Recent evidence suggests that insufficient heat shock proteins (HSPs) may contribute to apoptosis and muscle wasting. In addition, long-term caloric restriction (CR) and lifelong wheel running exercise (WR) with CR provide significant prot...

journal_title：Experimental gerontology

authors： Kim JH,Lee Y,Kwak HB,Lawler JM

更新日期：2015-09-01 00:00:00

abstract：INTRODUCTION:The SarcoPhAge project is an ongoing longitudinal study following community-dwelling elderly subjects with the objective to assess some health and functional consequences of sarcopenia. The sarcopenia diagnosis algorithm developed by the European Working Group on Sarcopenia in Older People (EWGSOP) and use...

journal_title：Experimental gerontology

authors： Beaudart C,Reginster JY,Petermans J,Gillain S,Quabron A,Locquet M,Slomian J,Buckinx F,Bruyère O

更新日期：2015-09-01 00:00:00

abstract：THE AIM:The aim of this study was to determine whether polymorphisms of the VDR gene may increase the risk of Alzheimer disease (AD) development in Lower Silesian patients in comparison with other populations. MATERIAL AND METHODS:108 AD patients (aged 73.7±8.6) vs 77 healthy volunteers (aged 64.5±7.8) in the Lower Si...

journal_title：Experimental gerontology

authors： Łaczmański Ł,Jakubik M,Bednarek-Tupikowska G,Rymaszewska J,Słoka N,Lwow F

更新日期：2015-09-01 00:00:00

abstract：INTRODUCTION:Right ventricular dysfunction (RVD), submassive pulmonary embolism (PE), elevated systolic pulmonary artery pressure (sPAP), elevated cardiac troponin I (cTnI) and old age are well-known risk factors for poor outcome in acute normotensive PE. The aim of this analysis was to calculate age cut-off values to ...

journal_title：Experimental gerontology

authors： Keller K,Beule J,Coldewey M,Geyer M,Balzer JO,Dippold W

更新日期：2015-09-01 00:00:00

abstract：:Spectrins are a part of cytoskeletal platform that lines the intracellular side of plasma membrane, which can be proteolyzed by calcium-sensitive enzymes including calpains and caspases. Caspase-3 mediated αII-spectrin proteolysis results in the release of a 120kDa spectrin breakdown product (SBDP120), known to occur ...

journal_title：Experimental gerontology

authors： Zhu HX,Xue ZQ,Qiu WY,Zeng ZJ,Dai JP,Ma C,Luo XG,Yan XX

更新日期：2015-09-01 00:00:00

abstract：:Psychological stress has often been described as a feeling of being overwhelmed by the necessity of constant adjustment to an individual's changing environment. Stress affects people of all ages, but the lives of the elderly may particularly be affected. Major changes can cause anxiety leading to feelings of insecurit...

journal_title：Experimental gerontology

authors： Moreno-Villanueva M,Bürkle A

更新日期：2015-08-01 00:00:00

abstract：OBJECTIVE:Senescent patients exhibit an elevated perioperative risk for cardiac dysfunction, hemodynamic depression and subsequent cardiac death compared to young patients. Despite the fact that a growing proportion of cardiac surgery patients are octogenarians, cardioplegic regimes remain comparable across patients of...

journal_title：Experimental gerontology

authors： Böning A,Rohrbach S,Kohlhepp L,Heep M,Hagmüller S,Niemann B,Mühlfeld C

更新日期：2015-07-01 00:00:00

abstract：OBJECTIVE:This study aimed to evaluate the effect of vitamin D3 megadose supplementation and influence of BsmI polymorphism in the VDR gene on the inflammatory profile and oxidative stress in elderly women with vitamin D deficiency. METHODS:A double blind, randomized, placebo-controlled trial was conducted with 40 eld...

journal_title：Experimental gerontology

authors： de Medeiros Cavalcante IG,Silva AS,Costa MJ,Persuhn DC,Issa CT,de Luna Freire TL,da Conceição Rodrigues Gonçalves M

更新日期：2015-06-01 00:00:00

abstract：:Cellular aging plays a role in longevity and senescence, and has been implicated in medical and psychiatric conditions, including heart disease, cancer, major depression and posttraumatic stress disorder. Telomere shortening and mitochondrial dysfunction are thought to be central to the cellular aging process. The pre...

journal_title：Experimental gerontology

authors： Tyrka AR,Carpenter LL,Kao HT,Porton B,Philip NS,Ridout SJ,Ridout KK,Price LH

更新日期：2015-06-01 00:00:00

abstract：:During aging declining maximum force capacity with more or less unchanged fatigability is observed with the underlying mechanisms still not fully understood. Therefore, we compared morphology and function of skeletal muscles between different age groups. Changes in high-energy phosphate turnover (PCr, Pi and pH) and m...

journal_title：Experimental gerontology

authors： Hiepe P,Gussew A,Rzanny R,Kurz E,Anders C,Walther M,Scholle HC,Reichenbach JR

更新日期：2015-05-01 00:00:00

abstract：:Although galanin has been shown to increase GLUT4 expression in the cardiac muscle of rats, there is no literature available about the effect of GalR1 on GLUT4 expression in the cardiac muscle of type 2 diabetic rats. The aim of this study was to determine whether intracerebroventricular injection of GalR1 agonist M61...

journal_title：Experimental gerontology

authors： Fang P,Shi M,Zhu Y,Zhang Z,Bo P

更新日期：2015-05-01 00:00:00

abstract：:There is an age-associated reduction in the bone healing activity of bone morphogenetic protein-2 (BMP-2) that is currently addressed by administering higher doses of BMP-2 in elderly patients. The unwanted medical complications from high dose BMP-2 motivated this investigation to determine whether the addition of a l...

journal_title：Experimental gerontology

authors： Charles LF,Woodman JL,Ueno D,Gronowicz G,Hurley MM,Kuhn LT

更新日期：2015-04-01 00:00:00

abstract：:Physical activity may help to prevent or delay brain atrophy. Numerous studies have shown associations between physical activity and age-related changes in the brain. However, most of these studies involved self-reported physical activity, not objectively measured physical activity. Therefore, the aim of this study wa...

journal_title：Experimental gerontology

authors： Doi T,Makizako H,Shimada H,Tsutsumimoto K,Hotta R,Nakakubo S,Park H,Suzuki T

更新日期：2015-02-01 00:00:00

abstract：BACKGROUND/OBJECTIVES:Geriatric patients are highly susceptible to infections. While reduced lymphocyte count has been associated with age, other studies found no change in WBC counts with age. Increased circulating white blood cell (WBC) count has been associated with cardiovascular (CV) diseases and frailty but there...

journal_title：Experimental gerontology

authors： Compté N,Bailly B,De Breucker S,Goriely S,Pepersack T

更新日期：2015-01-01 00:00:00

abstract：:This study investigated the effects of two training programmes of 6 weeks combining strength and balance exercises in different proportions. One training programme [n=10; 71.4 (6.3) years] consisted mainly of strength exercises (ST) and the other programme [n=8; 71.4 (6.4) years] included a majority of balance exercis...

journal_title：Experimental gerontology

authors： Penzer F,Duchateau J,Baudry S

更新日期：2015-01-01 00:00:00

abstract：:Accumulation of myeloid-derived suppressor cells (MDSCs) in aged hosts contribute to the age-related increase of susceptibility to murine breast adenocarcinoma and co-stimulatory molecules expressed in MDSCs are essential for MDSCs-mediated immune suppression. However, the co-stimulatory molecules that exert a direct ...

journal_title：Experimental gerontology

authors： Chen S,Liu H,Su N,Zhang G,Wang L

更新日期：2015-01-01 00:00:00

abstract：:Cinnamon is a spice commonly used worldwide to flavor desserts, fruits, cereals, breads, and meats. Numerous health benefits have been attributed to its consumption, including the recent suggestion that it may decrease blood glucose levels in people with diabetes. Insulin signaling is an integral pathway regulating th...

journal_title：Experimental gerontology

authors： Schriner SE,Kuramada S,Lopez TE,Truong S,Pham A,Jafari M

更新日期：2014-12-01 00:00:00

abstract：:Melatonin, the main product synthesized by the pineal gland, modulates several brain functions through different mechanisms, some of them involving the activation or participation of calcium binding intracellular proteins, such as the alpha calcium dependent protein kinase C and calmodulin. Another calcium-binding pro...

journal_title：Experimental gerontology

authors： Ramírez-Rodríguez G,Gómez-Sánchez A,Ortíz-López L

更新日期：2014-12-01 00:00:00

abstract：OBJECTIVE:To assess the effect of genetic and non-genetic factors on indicators derived from waist circumference (WC) and body mass index (BMI) as well as inter-indicator differences in risk assessment age-related diseases including diabetes mellitus, coronary heart disease and liver cancer. METHODS:Height, weight and...

journal_title：Experimental gerontology

authors： Xin G,Shong L,Hui L

更新日期：2014-12-01 00:00:00

abstract：BACKGROUND:Critically ill intensive care patients are subjected to controlled mechanical ventilation (CMV) which has an important association in triggering the impaired muscle function and the consequent delayed weaning from the respirator. AIM:The main aim of this study was to measure the effects of age and CMV over ...

journal_title：Experimental gerontology

authors： Cacciani N,Ogilvie H,Larsson L

更新日期：2014-11-01 00:00:00